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KMID : 0370219820260040189
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Yakhak Hoeji
1982 Volume.26 No. 4 p.189 ~ p.196
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Syntheses and Central Nervous Depressant Activity of Piperine Derivatives(Ⅰ)
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林中基/Rim, Joong Ki
李東雄/李眞榮/金蓮順/禹源植/李殷芳/Lee, Dong Ung/Lee, Jin Young/Kim, Youn Sun/Woo, Won Sick/Lee, Eun Bang
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Abstract
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Piperine was reported to have a potential central nervous system (CNS) depressant activity in mice. In order to search a more active and less toxic compound than piperine and to elucidate the active group of piperine, the aromatic amides (10 compeunds) and aromatic esters (10 cempounds) of 3, 4-methylenedioxycinnamic acid were synthesized and evaluated on CNS depressant activity in comparison with piperine. The pharmacological tests conducted are as follows; (1) Acute toxicity, (2) Antagonism against strychnine induced conduced convulsion, (4) Antagonism against maximal electroshock seizure, (5) Rotarod test, (6) Potentiation of hexobarbital sleeping time. It was observed that 3, 4-methylendioxycinanamic acid derivatives were less toxic than piperine, and showed no significant CNS depressant activities. These facts indicate that the piperoyl group might be concerned with the pharmacological activity of piperine.
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